Early Life Stress Major Risk Factor for Adult Depression

Jim Liebelt | Senior Editor of Publications for HomeWord | Monday, November 02, 2015

Early Life Stress Major Risk Factor for Adult Depression

*The following is excerpted from an online article from PsychCentral.

New research may help to explain how early life stressors can so dramatically affect mental health in adulthood.

The discovery is important because stress during the formative years, including abuse or emotional neglect, increases the risk for adult depression by nearly two-fold.

Scientific research into this link has revealed that the increased risk following such childhood adversity is associated with sensitization of the brain circuits involved with processing threat and driving the stress response.

Emerging findings are now demonstrating that in addition to the stress sensitization, there may also be diminished processing of reward in the brain. This deficit may diminish a person’s ability to experience positive emotions.

In the new study, researchers at Duke University and the University of Texas Health Sciences Center at San Antonio looked specifically at this second phenomenon in a longitudinal neuroimaging study of adolescents. Their intent was to gain a better understanding of how early life stress contributes to depression.

They recruited 106 adolescents, between the ages of 11-15, who underwent an initial magnetic resonance imaging scan, along with measurements of mood and neglect. The study participants then had a second brain scan two years later.

The researchers focused on the ventral striatum, a deep brain region that is important for processing rewarding experiences as well as generating positive emotions, both of which are deficient in depression.

They discovered that over a two-year window during early to mid-adolescence, there was an abnormal decrease in the response of the ventral striatum to reward only in adolescents who had been exposed to emotional neglect.

Emotional neglect is a relatively common form of childhood adversity where parents are persistently emotionally unresponsive and unavailable to their children, explains first author Dr. Jamie Hanson.

“Importantly, we further showed that this decrease in ventral striatum activity predicted the emergence of depressive symptoms during this key developmental period,” he added.

“Our work is consistent with other recent studies finding deficient reward processing in depression, and further underscores the importance of considering such developmental pathways in efforts to protect individuals exposed to childhood adversity from later depression.”

This study suggests that, in some people, early life stress compromises the capacity to experience enthusiasm or pleasure. In addition, the effect of early life stress may grow over time so that people who initially appear resilient may develop problems later in life.

“This insight is important because it suggests a neural pathway through which early life stress may contribute to depression,” said Dr. John Krystal, Editor of Biological Psychiatry.

Source: PsychCentral